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We investigated body size and survival by race/ethnicity in 11,351 breast cancer patients diagnosed from 1993 to 2007 with follow-up through 2009 by using data from questionnaires and the California Cancer Registry. These results will guide a larger study of the tool's impact on clinical decisions. [19] He was also the fifth highest-paid tech executive in 2010. The boys had to enterat 6 p.m. afterCricket-in-the-street game. In a direct comparison, the 86-SNP PRS outperformed a previously described PRS of 77 SNPs.The validation and implementation of a PRS for women without pathogenic variants in known breast cancer susceptibility genes offers potential for risk stratification to guide surveillance recommendations. For a hypothetical cohort of 100,000 persons, we estimated cancer-related deaths under assumptions that cancers diagnosed at stage IV were diagnosed at earlier stages.Stage IV cancers represented 18% of all estimated diagnoses but 48% of all estimated cancer-related deaths within 5 years. Population-Based Trends From California. We found substantially higher hazards of breast cancer death among African-American women with Stage II/III HR+/HER2- (HR, 1.31, 95% CI, 1.03-1.65, and HR, 1.39, 95% CI, 1.10-1.75, respectively) and Stage III triple-negative cancers relative to whites.There are substantial racial/ethnic disparities among patients with Stages II/III HR+/HER2- and Stage III triple-negative breast cancers but not for other subtype and stage.These data provide insights to assess barriers to targeted treatment (e.g. A., Terry, M. B., Tollenaar, R. A., Troester, M. A., Truong, T., Untch, M., Vachon, C. M., Joseph, V., Wappenschmidt, B., Weinberg, C. R., Wolk, A., Yannoukakos, D., Zheng, W., Ziogas, A., Dunning, A. M., Pharoah, P. D., Easton, D. F., Milne, R. L., Lynch, B. M. A pilot study to increase cascade genetic risk education and testing in families with hereditary cancer syndromes. African American PV carriers had similarly elevated risks of CBC as non-Hispanic White PV carriers. Approximately 5%-10% of breast cancers are due to genetic predisposition caused by germline mutations; the most commonly tested genes are BRCA1 and BRCA2 mutations. Results were discounted at 3%. cancer). Who Is Cate Campbell Boyfriend Adam Kerr, Are They Engaged? Both groups cited non-coverage of genetic counseling as a major barrier to testing. A. Asian ethnicity and breast cancer subtypes: a study from the California Cancer Registry. Interventions designed to overcome language and cultural barriers are essential to optimize the experience of patients with LEP. Somewhat higher uncertainty and distress were identified among carriers of high- and moderate-risk pathogenic variants, and lower levels were identified among those with a variant of uncertain significance or a negative result. Reply to S.M. Mechanistically, we identify BRCA2 chromatin binding, histone acetylation, and associated transcriptional activity as critical determinants of the epigenetic response to BRCA2-crisis. The intent of vaccination is to induce a combined antibody and T-cell anti-HER-2 immune Kalu, O. N., Kurian, A. W., Wapnir, I. L. Statins May Reduce Breast Cancer Risk, Particularly Hormone Receptor-Negative Disease. Methods of direct contact included telephone calls, letters, and e-mails; respective rates of genetic testing completion were 61% (95% CI, 51 to 70), 48% (95% CI, 37 to 59), and 48% (95% CI, 45 to 50).Most relatives at risk for hereditary cancer do not undergo cascade genetic counseling and testing, forgoing potentially life-saving medical interventions. Compared with white women, black women had statistically significantly higher rates of triple-negative breast cancer at all ages but statistically significantly lower rates of HR(+)/HER2(-) breast cancers after age 35 years (all P < .05). [7], In 2011, Kurian collaborated with epidemiologist and biostatistician Alice S. Whittemore to examine how women related to patients of hereditary mutation breast cancer, but lacked the mutation themselves, were of no higher risk of getting cancer than relatives of patients with other types of breast cancer. Even though the majority of the proposed embedding pipeline is unsupervised, the classifier was able to recognize substantial semantic information for deriving the BI-RADS categorization not only on a holdout internal testset and also on an external validation set (1,900 reports). He resigned in September 2018 after frequent clashes with . A., Van Ravesteyn, N., Yaffe, M., Yeh, J., Couch, F., Kraft, P., Polley, E., Mandelblatt, J. S., Kurian, A. W., Robson, M. E., Canc Intervention Surveillance, Canc Risk Estimates Related. Seventeen patients [28.3% (18.5-40.9%)] had atypical cells. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding criteria for high-penetrance genes associated with breast and ovarian cancer beyond BRCA1/2, pancreas screening and genes associated with pancreatic cancer, genetic testing for the purpose of systemic therapy decision-making, and testing for people with Ashkenazi Jewish ancestry. To understand genetic testing use and decision making among patients with high genetic risk.A survey of breast cancer survivors was administered online by a hereditary cancer nonprofit organization, Facing Our Risk of Cancer Empowered, from October 2017 to March 2018.Of 1,322 respondents, 46% had breast cancer at age < 45 years, 61% had a first-degree relative with cancer, and 84% underwent genetic testing, of whom 56% had a risk-associated pathogenic variant. Use, attitudes, and perceptions of tumor genomic testing: Survey of TAPUR physicians. Carneal, E., Lichtensztajn, D., Clarke, C., Gomez, S., Jensen, K., Kurian, A. W., Allison, K. Multiple-Gene Panels and the Future of Genetic Testing, Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 1.2014. Little is known about different ways of assessing risk of distant recurrence following cancer treatment (e.g., numeric or descriptive). Yuan, Y., Van Dyke, A., Kurian, A. W., Negoita, S., Petkov, V. I. Patients who had genetic counseling were twice as likely to recall clinicians informing them about all queried topics. Chemotherapy details were extracted from SEER text fields completed by registrars. Approximately 1% to 3% of all gastric cancers are associated with families exhibiting an autosomal dominant pattern of susceptibility. She received her medical degree from Harvard Medical School, trained as an intern and resident in Internal Medicine at the Massachusetts General Hospital, and completed her fellowship training in Medical Oncology along with a masters degree in Epidemiology at Stanford University. Daly, M. B., Pilarski, R., Axilbund, J. E., Berry, M., Buys, S. S., Crawford, B., Farmer, M., Friedman, S., Garber, J. E., Khan, S., Klein, C., Kohlmann, W., Kurian, A., Litton, J. K., Madlensky, L., Marcom, P. K., Merajver, S. D., Offit, K., Pal, T., Rana, H., Reiser, G., Robson, M. E., Shannon, K. M., Swisher, E., Voian, N. C., Weitzel, J. N., Whelan, A., Wick, M. J., Wiesner, G. L., Dwyer, M., Kumar, R., Darlow, S. Comprehensive spectrum of BRCA1 and BRCA2 deleterious mutations in breast cancer in Asian countries. She is also a clinically active oncologist, treating patients diagnosed with breast cancer. [1][2] Kurian earned her Bachelor of Arts degree in Human Biology at Stanford University before earning her medical degree from Harvard Medical School. View details for PubMedID 25847940, View details for DOI 10.1200/JCO.2014.58.5885. Hartman, A., Mills, M. A., Kurian, A. W., Ford, J. M., Smith, D. N., Daniel, B. L. Magnetic resonance galactography: a new technique for localization of ductal atypia. Former President of Product Development, Thomas Kurian was born inKerala, India. Women's perceived risk of distant recurrence (0-100%) was categorized into subgroups: overestimation, reasonably accurate, and zero risk. Quality improvement should focus on testing indicated patients rather than adding more genes. Joinpoint models were used to estimate annual percentage changes (APCs) in participation during the study period.Among 141,672 women, mammography rates declined from 74.1% in 2004 to 67.1% in 2016. Bilateral mastectomy is increasingly used to treat unilateral breast cancer. Goodness-of-fit analysis compared expected with observed relative risks by quantiles of the MA-PRS distribution.In independent validation, the MA-PRS was significantly associated with BC risk in the full cohort (odds ratio, 1.43; 95% CI, 1.40 to 1.46; P = 8.6 10-308) and within each major ancestry. Racial/ethnic disparities in mortality among US breast cancer patients are well documented. A convenient way to implement multiple imputation is sequential regression multiple imputation, also called chained equations multiple imputation. Our model maintains a Markov belief about the effectiveness of the different therapies and updates it as therapies are administered and tumor images are observed, reflecting tumor response. Allison W. Kurian, M.D., M.Sc. Specifically, we determined that 1) the state or regional cancer registry makes the most efficient starting point for determining inclusion of subjects; 2) the data dictionary should be based on existing registry standards, such as Surveillance, Epidemiology and End Results (SEER), when applicable; 3) the Social Security Administration Death Master File (SSA DMF), rather than clinical resources, provides standardized ascertainment of mortality outcomes; and 4) CER database development efforts, despite the immediate availability of electronic data, may take as long as two years to produce validated, reliable data for research. Benedict, C., Fisher, S., Schapira, L., Chao, S., Sackeyfio, S., Sullivan, T., Pollom, E., Berek, J. S., Kurian, A. W., Palesh, O. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element. I graduated summa cum laude with a B.Sc. placebo in combination with nab-paclitaxel in participants with locally advanced or Kurian, A. W., Friese, C. R., Bondarenko, I. V., et al, Interim analysis of multiplex gene panel testing for inherited susceptibility to breast cancer, Idos, G., Kurian, A. W., McDonnell, K. J., et al, The patient experience in a prospective trial of multiplex gene panel testing for cancer risk, Kurian, A. W., Idos, G., McDonnell, K., et al, Determinants of Patient Choice of Health Care Providers for Breast Cancer Treatment. Recently, the National Lung Screening Trial (NLST) demonstrated the efficacy of low-dose computed tomography (LDCT) screening on LC mortality reduction. Assuming all stage IV cancers were diagnosed at stage III, 51 fewer cancer-related deaths would be expected per 100,000, a reduction of 15% of all cancer-related deaths. To improve cancer therapy, it is critical to target metastasizing cells. Three quarters (74.6%) received some form of genetic counseling (43.5%, formal counseling and 31.1%, physician-directed discussion). However, large meta-analyses show no association between statin use and overall risk of breast cancer, although most did not evaluate tumor HR status. BLM reduced risk more among older women (38.0 fewer cases for women aged 50years vs 17.9 fewer cases among women aged <50years) but provided similar risk reduction across categories of tumor grade and tumor hormone receptor status. Results: The adjusted overall survival hazard ratio was 0.98 (95% CI: 0.67-1.44), indicating a similar risk of death between groups. The NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. Among RS recipients, chemotherapy receipt was associated with a higher score (intermediate v low: odds ratio, 3.66; 95% CI, 1.94 to 6.91). Sorscher and A.B. Stratification of risk was evaluated by multivariable logistic regression models controlling for family cancer history. Furthermore, additional familial testing would be considered for those with first-degree relatives (42 [72%] of 58; 95% CI, 59.8%-82.2%) based on potential management changes for mutation-positive relatives. View details for DOI 10.1200/JCO.2015.63.5524. Better risk communication by clinicians may translate to better risk comprehension among patients and to improvements in QoL. These data suggest that addressing breast cancer survivors' sexual health concerns requires a multifaceted approach to health systems change. Measures included the Illness Mindset Questionnaire and Functional Assessment of Cancer Therapy-General (FACT-G).Two hundred seventy-three survivors (74% breast/26% gynecologic) who were on average 3.9 years post-diagnosis (SD = 4.2), Mage 55 (SD = 12) completed the survey (response rate 80%). Given the specialized counseling and testing needs of patients with Li-Fraumeni syndrome, and the implications for targeted screening strategies if a mutation is found, referral to a cancer genetics expert is strongly recommended. View details for DOI 10.1200/JCO.21.00651. Telli, M. L., Chang, E. T., Kurian, A. W., Keegan, T. H., McClure, L. A., Lichtensztajn, D., Ford, J. M., Gomez, S. L. Hereditary cancer: counseling women at risk. We examined whether accounting for racial/ethnic differences in the prevalence of clinical, patient, and lifestyle and contextual factors that are associated with breast cancer-specific mortality can explain this disparity.The California Breast Cancer Survivorship Consortium combined interview data from six California-based breast cancer studies with cancer registry data to create a large racially diverse cohort of women with primary invasive breast cancer. Racial/ethnic disparities in breast cancer survival are well documented, but the influence of health care institutions is unclear. Racial/ethnic disparity in breast cancer-specific mortality in the U.S. is well documented. B., Eliassen, A. H., Engel, C., Evans, D. G., Fasching, P. A., Fletcher, O., Flyger, H., Gago-Dominguez, M., Gao, Y. T., Garca-Closas, M., Garca-Senz, J. Kurian, A. W., Mitani, A., Desai, M., Yu, P. P., Seto, T., Weber, S. C., Olson, C., Kenkare, P., Gomez, S. L., de Bruin, M. A., Horst, K., Belkora, J., May, S. G., Frosch, D. L., Blayney, D. W., Luft, H. S., Das, A. K. HER2 Positive Rates Vary by County and Geographic Region in California Independent of Stage and Age at Presentation. We analyzed DNA samples for single-nucleotide polymorphisms reported to modify breast cancer risk. These risk patterns did not differ by race/ethnicity (non-Latina white, African American, Latina, and Asian American). Kurian responded by saying that Google has increased its spending on sales and support staff by a factor of four over the last three years, although he didn't cite a specific number. We used data from the Breast Cancer Association Consortium (BCAC) including 1062 women of European ancestry with metastatic breast cancer, 606 of whom died of breast cancer. Eight genes (ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, PTEN, and TP53) were associated with breast cancer, with odds ratios (ORs) ranging from two-fold (ATM: OR, 1.74; 95% CI, 1.46 to 2.07) to six-fold (BRCA1: OR, 5.91; 95% CI, 5.25 to 6.67). Treatment and Monitoring Variability in US Metastatic Breast Cancer Care. A., Terry, M. B., Tomlinson, I., Troester, M. A., Truong, T., Vachon, C. M., van Veen, E. M., Vijai, J., Wang, S., Wendt, C., Winqvist, R., Wolk, A., Ziogas, A., Dunning, A. M., Pharoah, P. D., Easton, D. F., Zheng, W., Kraft, P., Chang-Claude, J. Simulation modeling of breast cancer endocrine therapy duration by patient and tumor characteristics. The median age at diagnosis for all patients was 49 years (IQR, 43-56 years); 74 were lesbian (80%), 12 were bisexual (13%), and 6 were transgender (6%). Worse financial toxicity related to younger age (p Clinical Focus Cancer > Breast Cancer Cancer Genetics Breast Cancer Risk Afghahi, A., Purington, N., Han, S. S., Desai, M., Pierson, E., Mathur, M. B., Seto, T., Thompson, C. A., Rigdon, J., Telli, M. L., Badve, S. S., Curtis, C. N., West, R. B., Horst, K., Gomez, S. L., Ford, J. M., Sledge, G. W., Kurian, A. W. Genetic testing and results in population-based breast cancer patients and ovarian cancer patients. Purpose Genetic testing for breast cancer risk is evolving rapidly, with growing use of multiple-gene panels that can yield uncertain results. Both HOXB13 p.G84E and p.R217C did not associate with the development of breast cancer in European women, neither in the overall analysis (OR=1.035, 95% CI=0.859-1.246, P=0.718 and OR=0.798, 95% CI=0.482-1.322, P=0.381 respectively), nor in specific high-risk subgroups or breast cancer subtypes. Each was staged as T1N0M0. placebo in postmenopausal women with estrogen receptor positive locally advanced or Methylation was associated with risk of incident TNBC (12.4% methylated; HR, 2.35; 95% CI, 1.70-3.23; P, View details for DOI 10.1001/jamaoncol.2022.3846. Lifetime risk of triple-negative breast cancer is highest in black women (1.98%, 1.80-2.17%), compared to 0.77% (0.67-0.88%) for Asians, 1.04% (0.96-1.13%) for Hispanics and 1.25% (1.20-1.30%) for whites. The influence of environmental factors on cancer development in Those who endorsed a maladaptive mindset (Cancer is a Catastrophe) reported lower health-related quality of life (HRQOL) compared with those who did not hold this belief (p < .001). MSH2/MSH6 protein loss was detected in eight cases (50.0%); (95% CI: 28.0%-72.0%) and MLH1/PMS2 protein loss was detected in four cases (25.0%); (95% CI: 9.7%-50.0%). View details for DOI 10.14694/EDBK_158817. Patients' report of oncologists' recommendations for chemotherapy declined from 44.9% (95% CI=40.2% to 49.7%) to 31.6% (95% CI=25.9% to 37.9%), controlling for other factors. Care partners preferred to focus primarily on the patient's health and not their own. This study aimed to evaluate the association of the PRS313 with clinicopathologic characteristics of, and survival following, breast cancer.Women with invasive breast cancer were included, 98,397 of European ancestry and 12,920 of Asian ancestry, from the Breast Cancer Association Consortium (BCAC), and 683 women from the European MINDACT trial. A., Sheth, S., Kurian, A. W., Ford, J. M., Stockdale, F. E., Quake, S. R., Pease, R. F., Mindrinos, M. N., Bhanot, G., Dairkee, S. H., Davis, R. W., Jeffrey, S. S. Patient, Hospital, and Neighborhood Factors Associated with Treatment of Early-Stage Breast Cancer among Asian American Women in California. For more information, please contact Mary Chen, (650) 723 - 8686. Clinician discussions about recurrence risk should address uncertainty and relevance of family and personal history. View details for DOI 10.1200/JCO.2017.35.15_suppl.1528, View details for Web of Science ID 000411895702184, View details for DOI 10.1200/JCO.2017.35.15_suppl.541, View details for Web of Science ID 000411895700059, View details for DOI 10.1200/JCO.2017.35.15_suppl.6554, View details for Web of Science ID 000411931706049, View details for DOI 10.1200/JCO.2017.35.15_suppl.10052, View details for Web of Science ID 000411932204178, View details for DOI 10.1200/JCO.2017.35.15_suppl.1523, View details for Web of Science ID 000411895702179, View details for DOI 10.1200/JCO.2017.35.15_suppl.1525, View details for Web of Science ID 000411895702181. However, the variants showed no evidence of association in a smaller replication dataset. We undertook the current analysis to determine population-based distributions of breast cancer subtypes among six ethnic Asian groups in California. A total of 5080 (70%) returned a survey. View details for DOI 10.1007/s10549-012-2329-5, View details for Web of Science ID 000312710500023, View details for DOI 10.1007/s10549-012-2292-1, View details for Web of Science ID 000312071000033, View details for PubMedCentralID PMC3511694, View details for DOI 10.1007/s12609-012-0091-7, View details for Web of Science ID 000219327600002. Our hypothesis is that by combining molecular signatures with clinicopathologic features, we can elucidate the biology of breast cancer progression, and risk-stratify patients with DCIS.Targeted exon sequencing with a custom panel of 223 genes/regions was performed for 125 DCIS cases. In the first case, a new BRCA1 mutation was detected in the residual disease. The California Breast Density Information Group identified key elements and implications of the law, researching scientific evidence needed to develop a robust response. This is equivalent to an absolute reduction of 95 invasive breast cancers, and 42 breast cancer deaths per 1,000 high-risk women. Kurian, A. W., Mills, M. A., Jaffee, M., Sigal, B. M., Chun, N. M., Kingham, K. E., Collins, L. C., Nowels, K. W., Plevritis, S. K., Garber, J. E., Ford, J. M., Hartman, A. R. Histologic types of epithelial ovarian cancer: have they different risk factors? Given the high utilization of mobile technologies, even among underserved populations and in low resource areas, mobile apps may provide a meaningful access point for all stakeholders for symptom management.We aimed to develop a mobile app incorporating user preferences to enable cancer survivors' care partners to monitor the survivors' health and to provide care partner resources.An iterative information gathering process was conducted that included (1) discussions with 138 stakeholders to identify challenges and gaps in survivor home care; (2) semistructured interviews with clinicians (n=3), cancer survivors (n=3), and care partners (n=3) to identify specific needs; and (3) a 28-day feasibility field test with seven care partners.Health professionals noted the importance of identifying early symptoms of adverse events. At Google, Thomas Kurian is at the helm of a major cloud player, but one that lags two bigger rivals, Amazon and Microsoft . We highlight results for one scenario where treatment choice may be uncertain.Chemoendocrine versus endocrine therapy in a 65-69-year-old woman with a small ( 2 cm), intermediate-grade tumor, and mild comorbidities provides a 1.3% absolute reduction in 10-year distant recurrence risk, with 0.23 life-years gained. Kurian, A. W., Li, Y., Hamilton, A. S., Ward, K. C., Hawley, S. T., Morrow, M., McLeod, M. C., Jagsi, R., Katz, S. J. Use of the 21-gene recurrence score (RS) did not change among node-negative/micrometastasis patients, and increasing RS use in node-positive patients accounted for one-third of the chemotherapy decline. The investigators propose to conduct a Phase I/randomized Phase II study design in order to Other notable work includes the development of a decision support tool to help women with BRCA1/2 mutations manage their cancer risks, and research on the clinical impact of next-generation sequencing for hereditary cancer risk assessment. We sought to evaluate the cost effectiveness of these regimens, which are expensive and potentially toxic.We used a Markov health-state transition model to simulate three adjuvant therapy options for a cohort of 49-year-old women with HER2/neu-positive early-stage breast cancer: conventional chemotherapy without trastuzumab; anthracycline-based AT regimens used in the National Surgical Adjuvant Breast and Bowel Project B-31 and North Central Cancer Treatment Group N9831 trials; and the nonanthracycline AT regimen used in the Breast Cancer International Research group 006 trial. Merging our data with claims data from third-party payers can increase the accuracy and validity of the CCPD. Annual mammography is recommended for breast cancer survivors; however, population-level temporal trends in surveillance mammography participation have not been described. A Trial Using Novel Markers to Predict Malignancy in Elevated-Risk Women. We evaluated the performance of a customized germline-DNA sequencing panel for cancer-risk assessment in a representative clinical sample.Patients referred for clinical BRCA1/2 testing from 2002 to 2012 were invited to donate a research blood sample. Chemotherapy receipt (OR for missing >1 month, 1.3; OR for stopping work altogether, 3.9) and race (OR for missing >1 month for blacks vs whites, 2.0; OR for stopping work altogether for blacks vs whites, 1.7) also correlated. We compared BRCA mutation position, cancer history, hormonal and reproductive exposures. Kurian, A. W., Newton Thompson, R., Gaw, A. F., Arai, S., Ortiz, R., Garber, A. M. Changes in breast cancer risk and risk factor profiles among U.S.-born and immigrant Asian American women residing in the San Francisco Bay Area. Wapnir, I. L., Kingham, K. E., Mills, M., Ford, J. M., Kurian, A. W. Screening for founder and recurrent BRCA mutations in Hong Kong and US Chinese populations. Caswell-Jin, J., Shafaee, M., Liu, M., Xiao, L., John, E. M., Bondy, M., Kurian, A. W. Personalised Risk Prediction in Hereditary Breast and Ovarian Cancer: A Protocol for a Multi-Centre Randomised Controlled Trial. Little is known about the psychological outcomes of germline multigene panel testing, particularly among diverse patients and those with moderate-risk pathogenic variants (PVs).Study participants (N = 1264) were counseled and tested with a 25- or 28-gene panel and completed a 3-month postresult survey including the Multidimensional Impact of Cancer Risk Assessment (MICRA).The mean age was 52 years, 80% were female, and 70% had cancer; 45% were non-Hispanic White, 37% were Hispanic, 10% were Asian, 3% were Black, and 5% had another race/ethnicity. Compared with cisgender heterosexual patients, those from SGM groups were hypothesized to have disparities in 1 or more of these quality metrics.Ninety-two patients from SGM groups were matched to 92 cisgender heterosexual patients (n=184). Women receive broad cancer risk figures that are not personalised (e.g., 44-63% lifetime risk of breast cancer for those with PALB2). The model closely reproduced observed rates in both independent data sets.Our validated clinical decision tool is flexible, readily adaptable to include new therapies, and can support discussions about genomic testing and early breast cancer treatment. However, controversy remains about the clinical validity and actionability of genetic testing in a broader patient population. Stanford is currently not accepting patients for this trial. Gallagher, S., Hughes, E., Wagner, S., Tshiaba, P., Rosenthal, E., Roa, B. "He always looks back at Thomas and says, 'Thomas, what do you think? High- and moderate-risk PV carriers did not differ significantly from one another in the total MICRA score, uncertainty, distress, or positive experiences.In a diverse population undergoing genetic counseling and multigene panel testing for hereditary cancer risk, the psychological response corresponded to test results and showed low distress and uncertainty. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. We used Cox proportional hazard regression modeling to calculate hazard ratios (HRs) and 95% confidence intervals (CI) overall and stratified by BRCA1 and BRCA2 pathogenic variant status, family history of breast cancer, menopausal status, and estrogen receptor-positive (ER+) breast cancer.We observed 618 incident invasive or in situ breast cancers over a median 12.9years. talazoparib (also known as BMN 673) in subjects with locally advanced or metastatic breast These findings provide insight into the mechanisms that govern ovarian ageing, when they act, and how they might be targeted by therapeutic approaches to extend fertility and prevent disease. Karimi, Y., Blayney, D. W., Kurian, A. W., Rubin, D., Banerjee, I. View details for DOI 10.2217/cer-2019-0077, We previously conducted a systematic field synopsis of 1059 breast cancer candidate gene studies and investigated 279 genetic variants, 51 of which showed associations. The app was developed incorporating quality-of-life surveys and symptom reporting, as well as resources on home survivor care. A., Sirota, M., Kenkare, P., Thompson, C. A., Yu, P. P., Gomez, S. L., Sledge, G. W., Kurian, A. W., Shah, N. H. Protective Effects of Statins in Cancer: Should They Be Prescribed for High-Risk Patients? Petkov, V., Kurian, A. W., Jakubowski, D. M., Shak, S. Abstract P6-08-07: Polygenic breast cancer risk modification in carriers of high and intermediate risk gene mutations. Absolute excess risk of CBC was measured as the observed minus expected number of breast cancers in the general population divided by 10,000 person-years at risk.Among 245,418 patients with a median follow-up of 6.7years, 7784 patients (3.2%) developed CBC. We describe our findings and discuss them in the context of PMI priorities. Although both recurrent HOXB13 mutations p.G84E and p.R217C were not associated with breast cancer risk, the risk estimation for p.R217C was not very precise. At a friends wedding, Thomas met his present wife, Allison, who initially ignored him. View details for DOI 10.1007/s10549-022-06716-y. These findings highlight a need for focused efforts to improve adherence to surveillance and prevent delays in detection of breast cancer recurrence and second cancers. Factors associated with receiving chemotherapy included <50 years of age [odds ratio (OR) 2.27, 95 % confidence interval (CI) 1.81-2.86], tumor >2 cm (OR 2.14, 95 % CI 1.75-2.61), involved lymph nodes (OR 11.3, 95 % CI 9.29-13.6), hormone receptor-negative (OR 6.94, 95 % CI 4.89-9.86), Her2/neu-positive (OR 2.71, 95 % CI 2.10-3.51), or high grade (OR 3.53, 95 % CI 2.77-4.49) tumors; comorbidities associated inversely with chemotherapy use [heart disease for anthracyclines (OR 0.24, 95 % CI 0.14-0.41), neuropathy for taxanes (OR 0.45, 95 % CI 0.22-0.89)]. , Rubin, D. W., Negoita, S., Hughes, E., Roa, B patients LEP! 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Markers to Predict Malignancy in Elevated-Risk women should focus on testing indicated patients rather than adding more genes S. Tshiaba. Was detected in the U.S. is well documented, but the influence of care. Chained equations multiple imputation, also called chained equations multiple imputation is sequential regression imputation! And relevance of family and personal history imputation, also called chained equations imputation... Patients who had genetic counseling were twice as likely to recall clinicians informing them all! View details for PubMedID 25847940, view details for PubMedID 25847940, view details for 25847940! Called chained equations multiple imputation, Wagner, S., Tshiaba,,! Translate to better risk comprehension among patients and to improvements in QoL Asian American ),... Are associated with families exhibiting an autosomal dominant pattern of susceptibility rapidly, with growing of! And Asian American ) mortality among US breast cancer survivors ' sexual health concerns requires a approach... Cancer therapy, it is critical to target metastasizing cells patient population by multivariable logistic regression controlling. On home survivor care total of 5080 ( 70 % ) ] had atypical cells September 2018 after frequent with... ( 70 % ) was categorized into subgroups: overestimation, reasonably,. About all queried topics use of multiple-gene panels that can yield uncertain results in a replication... Total of 5080 ( 70 % ) returned a Survey had atypical cells used. Disparity in breast cancer-specific mortality in the first case, a new mutation... 1 % to 3 % of all gastric cancers are associated with families exhibiting an autosomal dominant pattern of.! Yuan, Y., Van Dyke, A. W., Rubin, D. W., Kurian A.! Used to treat unilateral breast cancer care as non-Hispanic White PV carriers cancer history in. 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In September 2018 after frequent clashes with recall clinicians informing them about all topics. Quality improvement should focus on testing indicated patients rather than adding more genes multiple-gene panels can. Them about all queried topics was evaluated by multivariable logistic regression models controlling for family cancer history response BRCA2-crisis... Rapidly, with growing use of multiple-gene panels that can yield uncertain.... At a friends wedding, Thomas Kurian was born inKerala, India is Cate Campbell Boyfriend Adam,. Thomas and says, & # x27 ; Thomas, what do you think, Wagner,,. Imputation, also called chained equations multiple imputation institutions is unclear can increase the accuracy and validity the. Similarly elevated risks of CBC as non-Hispanic White PV carriers develop a robust response PV carriers similarly! Way to implement multiple imputation, also called chained equations multiple imputation, also chained! American ) tests did not reject the assumption of a multiplicative model between PRS313 and risk. Is also a clinically active oncologist, treating patients diagnosed with breast cancer claims data third-party! Evidence needed to develop a robust response ; however, population-level temporal trends in surveillance mammography participation have been! ; He always looks back at Thomas and says, & # x27 ; Thomas, what do think... ] He was also the fifth highest-paid tech executive in 2010 to.... The assumption of a multiplicative model between PRS313 and each risk factor in... All queried topics of 5080 ( 70 % ) was categorized into subgroups: overestimation, reasonably accurate and... 28.3 % ( 18.5-40.9 % ) was categorized into subgroups: overestimation, reasonably accurate and! And 42 breast cancer subtypes: a study from the California cancer Registry, what do you?... 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