Treatment: Treat to anemia in people with chronic kidney disease. This site needs JavaScript to work properly. Cases of PRCA and of severe anemia, with or without other cytopenias that arise following the development of neutralizing antibodies to erythropoietin have been reported in patients treated with Aranesp or EPOGEN. Conversion from Epoetin alfa or Darbepoetin alfa to Mircera in Adult Patients with CKD Mircera can be administered once every two weeks or once monthly to patients whose hemoglobin has been stabilized by treatment with an ESA (see Table 1). These adverse reactions included myocardial infarction and stroke. -, Macdougall IC. Serious allergic reactions, including anaphylactic reactions, angioedema, bronchospasm, skin rash, and urticaria may occur with Aranesp or EPOGEN. Use the lowest Mircera dose sufficient to reduce the need for red blood cell (RBC) transfusions. <>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>>
Packaging Type: Injection. Kidney Int.
Methoxy polyethylene glycol-epoetin beta | Drugs | BNF | NICE Adverse Reactions: Hypertension, diarrhea,.
PDF Drug Name: Erythropoietin Stimulating Agents (ESAs) Clinical Indication Recombinant human erythropoietin is effective in Karaboyas A, Morgenstern H, Fleischer NL, Vanholder RC, Dhalwani NN, Schaeffner E, Schaubel DE, Akizawa T, James G, Sinsakul MV, Pisoni RL, Robinson BM. For more information, please see the full Prescribing Information, including Boxed WARNING, and Medication Guide(English, Espaol) for MIRCERA. Learn about Mircera, potential side effects, proper use and dosing, and popular alternatives. DA, launched in 2001 [5, 7], contains 5 N-linked oligosaccharide chains, rather than the 3 contained in short-acting epoetins, which confer an approximately threefold longer serum half-life and mean residence time, allowing extended inter-dosing intervals [6]. m+KqXAXOkS@,1C0VgzXzeWU},4 Mircera belongs to a class of drugs called Hematopoietic Growth Factors. Before Discard any unused portion. Generic name: Methoxy polyethylene glycol-epoetin beta 30ug in 0.3mL 2014 Dec 8;2014(12):CD010590. Nephrol Dial Transplant. Disclaimer. 2010;25:400917. Nephrol Dial Transplant.
Mircera (methoxy polyethylene glycol / epoetin beta) dosing - Medscape doi: 10.1001/archinte.162.12.1401.
A Study Comparing Mircera and Epoetin Alfa for the Treatment of Anemia Aranesp (darbepoetin alfa), Dynepo (epoetin delta), Mircera (methyoxy polyethylene glycol-epoetin beta), Hematide, MRK-2578, INS-22, Retacrit (epoetin zeta), Neorecormon (epoetin beta), Silapo (epoetin zeta), Binocrit . Unable to load your collection due to an error, Unable to load your delegates due to an error. Fewer than half of the patients achieved Hb in the 1012g/dL range by 7months post-switch. Reasons for exclusion of 96 enrolled patients from the DCR analysis are presented in Fig. Data were also manually reviewed prior to final analysis. Of the 29 patients transfused during the post-switch period, 20 had a dose ratio at switch <1, and 9 had a dose ratio at switch 1 (odds ratio 2.39, 95% CI 1.05, 5.44; P=0.038).
Insertion mechanism for drug delivery device - AMGEN INC. Tables2 and 3 also summarize the proportion of patients in different Hb categories by study month. [citation needed] *Data from a multicenter, randomized, open-label study comparing epoetin, given 1, 2, or 3 times weekly IV or SC, with ARANESP , at a reduced dose frequency, in dialysis patients (N = 522).Dose adjustments were made as necessary and per study protocol to maintain individual patients' Hb within a target range of -1.0 to +1.5 g/dL of their baseline Hb and between 9 g/dL and 13 g/dL for up . In these hemodialysis patients switched from DA to PEG-Epo the DCR was 1.17 and 1.21 after accounting for the effect of transfusions. The conversion rate was 354:1 in patients requiring high (>200 IU/kg/week) doses of epoetin and 291:1 in patients requiring low doses. Epoetin alfa (Eprex [JanssenCilag], Binocrit [Sandoz], and epoetin zeta (Retacrit, - Hospira UK): the initial dose is 150 IU kg-1 given subcutaneously three times per week.5 -7 Alternatively, epoetin alfa can be administered at an initial dose of 450 IU kg 1 subcutaneously once weekly.5-7 The maximum recommended dose is 900 IU kg-1 When initiating or adjusting therapy, monitor hemoglobin levels at least weekly until stable, then monitor at least monthly. Epub 2011 Dec 2. doi: 10.1002/14651858.CD010590.pub2. 2001;38:80312. As shown in Tables2 and 3, the mean (standard error) monthly Hb remained stable across the observation period, with mean monthly concentration ranging from 11.42 (0.09) g/dL (Month 4) to 11.60 (0.09) g/dL (Month 2) pre-switch, and from 11.26 (0.10) g/dL (Month 4) to 11.67 (0.09) g/dL (Month 1) post-switch. See Instructions for Use for complete instructions on the preparation and administration of MIRCERA, If the hemoglobin level approaches or exceeds 11 g/dL, reduce or interrupt the dose of MIRCERA. Mircera is a prescription medicine used to treat the symptoms of Anemia associated with Chronic Renal Failure. . These findings were observed in studies of patients with advanced head and neck cancer receiving radiation therapy, in patients receiving chemotherapy for metastatic breast cancer or lymphoid malignancy, and in patients with non-small cell lung cancer or various malignancies who were not receiving chemotherapy or radiotherapy. In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL. 2013;28:10929. Conclusion: Mean Hb was 11.5g/dL in the pre-switch EP and 11.4g/dL in the post-switch EP. NCI CPTC Antibody Characterization Program, Astor BC, Muntner P, Levin A, Eustace JA, Coresh J. government site. AFFIRM (Aranesp Efficiency Relative to Mircera) was a retrospective, multi-site, observational study designed to estimate the population mean maintenance dose conversion ratio [DCR; dose ratio achieving comparable hemoglobin level (Hb) between two evaluation periods] in European hemodialysis patients whose treatment was switched from DA to PEG-Epo. No difference in conversion dosage could be determined between patients who were epoetin sensitive (<200 units/kg per week) or resistant (>200 units/kg per week, P = NS).
Erythropoietins: A common mechanism of action - Academia.edu reverse transcriptase polymerase chain reaction (RT-PCR) Amplification of RNA sequences by conversion to cDNA by nucleic acid hybridization A technique of nucleic acid reverse transcriptase, followed by the polymerase chain reac-analy sis via association of complementary single- stranded tion. HHS Vulnerability Disclosure, Help If severe anemia and low reticulocyte count develop during treatment with Aranesp or EPOGEN, withhold Aranesp or EPOGEN and evaluate patients for neutralizing antibodies to erythropoietin. Logistic regression analysis showed a higher likelihood of a transfusion during the post-switch period among patients with a dose ratio at switching of <1. Mircera : EPAR - Conditions imposed on member states for safe and effective use - Annex IV (PDF/15.49 KB) First published: 02/08/2007 Last updated: 02/08/2007 Pharmacotherapeutic group Antianemic preparations Therapeutic indication Treatment of symptomatic anaemia associated with chronic kidney disease (CKD). Conversion from Epoetin alfa or Darbepoetin alfa to Mircera in Pediatric Patients with CKD Treated with Hemodialysis Administer Mircera intravenously once every 4 weeks to pediatric patients (ages 5 to 17 years) whose hemoglobin level has been stabilized by treatment with an ESA. }"nUEcJumC0ooF doi: 10.1053/j.ajkd.2011.11.013. 3 DOSAGE FORMS AND STRENGTHS. The https:// ensures that you are connecting to the There is no evidence that Mircera alters the metabolism of other medicinal products. Do you wish to proceed? https://doi.org/10.1007/s12325-013-0063-y, DOI: https://doi.org/10.1007/s12325-013-0063-y. Hemoglobin level and weekly equivalent erythropoiesis-stimulating agent dose during the 14-month observation period. Mircera can be administered once every two weeks or once monthly to patients whose hemoglobin has been stabilized by treatment with an ESA (see Table 1). An official website of the United States government. Control hypertension prior to initiating and during treatment with Aranesp or EPOGEN. The distribution of Hb values reported within the 14days prior to transfusion was described; if multiple Hb values were recorded, the value closest to the transfusion date was utilized. In controlled clinical trials of patients with CKD comparing higher hemoglobin targets (13 to 14 g/dL) to lower targets (9 to 11.3 g/dL), ESAs increased the risk of death, myocardial infarction, stroke, congestive heart failure, thrombosis of hemodialysis vascular access, and other thromboembolic events in the higher target groups. It is not known if Mircera is safe and effective in children younger than 5 years of age. ribosome A ribonuclear protein complex that binds to mRNA nucleotide A basic .
Product Information and Dosing | Mircera MIRCERA is an erythropoiesis-stimulating agent (ESA) indicated for the treatment of anemia associated with chronic kidney disease (CKD) in: MIRCERA is not indicated and is not recommended for use: MIRCERA has not been shown to improve quality of life, fatigue, or patient well-being. Over the last 25years, several originator and biosimilar ESAs have been introduced for the management of CKD anemia, starting with the first generation short-acting recombinant erythropoietin agents (epoetin alfa and beta) and latterly with two longer-acting molecules, darbepoetin alfa (DA) and methoxy polyethylene glycol-epoetin beta (PEG-Epo), which combine a significantly increased half-life and lower binding affinity for the EPO receptor, allowing them to stimulate erythropoiesis for longer periods and to be administered less frequently [5, 6]. Section III: Treatment of renal anaemia. PRCA has also been reported in patients receiving ESAs for anemia related to hepatitis C treatment (an indication for which Aranesp and EPOGEN are not approved). The number of transfusions and units transfused increased approximately threefold from the pre-switch to the post-switch period. history of serious or severe allergic reactions to MIRCERA (e.g., anaphylactic reactions, angioedema, bronchospasm, pruritus, skin rash, and urticaria). 2).
MIRCERA- methoxy polyethylene glycol-epoetin beta Aranesp Dosing and Conversion Brochure | Amgen Anemia Hub Box 1557, 6301, Zug, Switzerland, Amgen (UK) Limited, 240 Cambridge Science Park, Milton Road, Cambridge, UK, You can also search for this author in J Manag Care Pharm. The data from this study were analyzed using SAS Statistical Software v9.2 (SAS Institute Inc., Cary, NC, USA). Disposition of patients. \ab/`IR 4%jI ^w7qQNA Tq Wz.oVfCVBT{h*>\\3u#P@"wW7|pIMB7 This analysis indicated that the concordance decreased with increasing dose. The .gov means its official.
Prise en charge anmie rnale - Nephro.blog _____ (if . The relationship between the DA and PEG-Epo doses during the evaluation periods was explored through linear and quadratic regression. PubMed There were 16 transfusions and 34 units transfused in the pre-switch period, versus 48 transfusions and 95 units transfused post-switch. Regression analysis indicated a non-linear relationship between pre- and post-switch ESA doses; DCR decreased with increasing pre-switch DA dose. EP evaluation period, PEG-Epo methoxy polyethylene glycol-epoetin beta. In conclusion, this study has shown that in a cohort of European hemodialysis patients who converted from DA to PEG-Epo (and who completed 67months treatment with PEG-Epo post-conversion), there was an approximately 20% increase in the g dose required to achieve a comparable Hb profile. Data were collected from 7 months before until 7 months after switching treatment.
Mircera solution for injection in pre-filled syringe W\iA* Galle JC, Claes K, Kiss I, Winearls CG, Herlitz H, Guerin A, Di Giulio S, Suranyi MG, Bridges I, Addison J, Farouk M. Nephrol Dial Transplant. PMC species. MIRCERA is contraindicated in patients with: Please seefull Prescribing Information including Boxed WARNING, and Medication Guide(English, Espaol)for MIRCERA (methoxy polyethylene glycol-epoetin beta) Injection, for Intravenous or Subcutaneous Use. volume30,pages 10071017 (2013)Cite this article. We comply with the HONcode standard for trustworthy health information. Tel: +1-650-344-3898 | Fax: +1-888-256-8883 | Email: info@palace-travel.com | | | LOG IN This paper presents the findings of a retrospective, multi-center, observational study of hemodialysis patients switched from DA to PEG-Epo for the treatment of anemia. Donck J, Gonzalez-Tabares L, Chanliau J, Martin H, Stamatelou K, Manamley N, Farouk M, Addison J. Adv Ther. 2012;59:44451. There were 16 transfusions and 34 units transfused in the pre-switch period, versus 48 transfusions and 95 units transfused post-switch. Methoxy polyethylene demonstrated that the dose efficiency after SC and IV ad- glycol-epoetin b (PEG-epoetin b; Mircera; F. Hoffmann- ministration was . DA can be administered once a week (QW) or once every 2weeks (Q2W) to hemodialysis patients.
PDF Mircera, INN: methoxy polyethylene glycol-epoetin beta before initiating Mircera [see Warnings and Precautions (5.9)]. An additional analysis was performed to explore the effect of transfusions on the DCR, by exclusion of patients with a transfusion within 90days prior to or during either EP from the analysis. Roche Registration Ltd., Welwyn Garden City, UK, 19 June 2012. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000739/WC500033672.pdf.
RETACRIT Dosage Forms and Strengths (epoetin alfa-epbx) The geometric mean DCR was 1.17 (95% CI 1.05, 1.29). x]r9r}W#k Locatelli F, Aljama P, Barany P, et al. DCR geometric mean maintenance dose conversion ratio, EP evaluation period, ESA erythropoiesis-stimulating agent, Hb hemoglobin, PEG-Epo methoxy polyethylene glycol-epoetin beta.
BlandAltman analysis of agreement between pre- and post-switch erythropoiesis-stimulating agent dose (. Dose by Weight Chart - Resourcehub Epogen Dosage Guide - Drugs.com Epogen, Procrit (epoetin alfa) dosing, indications, interactions
PDF Limitations of Use Mircera is not indicated and is not recommended for 2020 Mar 26;2(3):286-296. doi: 10.1016/j.xkme.2020.01.007. Mircera with 1-step decrease as soon as Hgb is < 11.8 g/dL and last dose was administered 2 weeks ago or more. Revised European Best Practice Guidelines for the management of anaemia in patients with chronic renal failure.
RETACRIT Dosage and Administration (epoetin alfa-epbx) in the treatment of anemia due to cancer chemotherapy. The dose of MIRCERA , given as a single intravenous or subcutaneous injection, should be based on the total weekly ESA dose at the time of conversion.
Mircera | European Medicines Agency Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Empirical methods to calculate an erythropoiesis-stimulating agent dose conversion ratio in nondialyzed patients with chronic kidney disease. Tolman et al. Aranesp (darbepoetin alfa) Epogen (epoetin alfa) Mircera . Conclusion: In patients on hemodialysis receiving ESAs, conversion from epoetin alfa to darbepoetin alfa was associated with an approximate and persistent reduction of 65% of the required dose. "BG0RjI G78 EPOGEN from multidose vials contains benzyl alcohol and is contraindicated in neonates, infants, pregnant women, and lactating women.
PDF Methoxy polyethylene glycol-epoetin beta (Mircera ) Protocol Brand: Mircera. Dosing patterns, drug costs, and hematologic outcome in anemic patients with chronic kidney disease switching from darbepoetin alfa to epoetin alfa. Choi, P., Farouk, M., Manamley, N. et al. HQ-MIR-1900027 Site last modified: January 2023. Low hemoglobin at hemodialysis initiation: an international study of anemia management and mortality in the early dialysis period. If Hb exceeds a level needed to avoid RBC transfusions, withhold dose until Hb approaches a level where RBC transfusions may be required and reinitiate at a dose 40% below the previous dose. Further exploration of the relationship between DA and PEG-Epo doses using the BlandAltman method [10], which circumvents the limitations of the regression method in this type of investigation, indicated that the variability in the dose differences increased as doses increased, while the level of concordance decreased with increasing ESA dose. In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL. Anemia of end-stage renal disease (ESRD) Kidney Int. Individualize dosing and use the lowest dose of Mircera sufficient to reduce the need for RBC transfusions [see Warnings and Precautions (5.1)]. Correct or exclude other causes of anemia (e.g., vitamin deficiency, metabolic or chronic inflammatory conditions, bleeding, etc.) 1. Matsumura K, Okumiya T, Sugiura T, Takahashi N, Yamamoto Y, Kikuchi S, Fujii K, Otagaki M, Shiojima I. BMC Nephrol. Contributed by. I certify that I am a healthcare professional in the US. BlandAltman analysis of agreement between pre- and post-switch erythropoiesis-stimulating agent dose (n=205). doi: 10.1038/ki.1985.109. 3 0 obj
Careers. A decade in the anaemia market - 10 products seen top . The number of RBC transfusions and units transfused in the post-switch period was approximately threefold higher compared to the pre-switch period.
aranesp to retacrit conversion Mechanism of Action. MIRCERA Classification: Erythropoiesis stimulating protein. Amgen Europe B.V., Breda, The Netherlands, 29 August 2013. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000332/WC500026149.pdf. Bland JM, Altman DG. There is limited information published on switching erythropoiesis-stimulating agent (ESA) treatment for anemia associated with chronic kidney disease (CKD) from darbepoetin alfa (DA) to methoxy polyethylene glycol-epoetin beta (PEG-Epo) outside the protocol of interventional clinical studies. A primary growth factor for erythroid development, erythropoietin is produced in the kidney and released into the bloodstream in response to hypoxia. pediatric patients 5 to 17 years of age on hemodialysis who are converting from another ESA after their hemoglobin level was stabilized with an ESA. Anemia of chronic kidney disease (CKD) becomes increasingly prevalent and severe as kidney function declines [1], with over 90% of patients who require renal replacement therapy becoming anemic [2]. Mircera is used to reduce or avoid the need for RBC transfusions. 2013;73:11730. pee`T"c+l_WB,`km^;6#j(*m`&E`l${F6Q`&^=e`f(6]8ZE[VHNx-FRIhE&iJKvW`Vz^p@?Yk+S.DgR1rrB6yq2N$|
Conversion Dosing Guide: from Epoetin Alfa to Aranesp in Patients with <>
Red blood cell transfusions pre- and post-switch were quantified. When administered subcutaneously, Mircera should be injected in the abdomen, arm or thigh. Aranesp (darbepoetin alfa) is indicated for the treatment of anemia due to chronic kidney disease (CKD), including patients on dialysis and patients not on dialysis.
Aranesp (darbepoetin alfa) | Dosing Considerations PubMed a Mutually exclusive categories; patients are censored in the following, Analysis of relationship between pre- and post-switch erythropoiesis-stimulating agent dose. Patients were then switched to fortnightly darbepoetin alfa dosing treatments; the existing weekly dose being doubled and Hb levels fell from 125 to 110 g/L (P < 0.0001), despite an increase in the mean dose from 44.9 to 47.5 .
Mircera is not the same as epoetin alfa (Procrit, Epogen).
Arch Intern Med. Nick Manamley, MSc, is an employee of Amgen with Amgen stock ownership.
PDF beta (Mircera ) Protocol - Northwest Kidney Centers Adverse reactions ( 5%) in EPOGEN clinical studies in patients with CKD were hypertension, arthralgia, muscle spasm, pyrexia, dizziness, medical device malfunction, vascular occlusion, and upper respiratory tract infection. ?z_IxD1&S&L)@g7NI\H |a_,I17KFu[7+n h?b}xqm5Ed]N8+3ei^Rh/0up20]S=NoPAN$Z$L+u'Hp5v;'QyBQT 8}"{=xVqe)gR&yOs^sfT#B cf#xF`=bXMdCV?s&KS|`q9HT=,[='q6s1UE J$KxBE hg*~'ct'p|YTs1c->uLd_614J)q)g>QR`~*B9GewhNBPs j
"It(Y%kRz}=!ayvw^`c]n986kR+LBZ:l~(hf !|p)-b=@|] aRQ:SIRwn$Ip 8v-S"-j0G;r:@ElyDkDE#4H~n{x4P*jS '.P4F lZhBW0t*1b`&wIU_=(>|@"1A`. eCollection 2020 May-Jun. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Introduction: National Library of Medicine
Pfizer's Retacrit, the First Erythropoietin Stimulating - BioSpace Dissertation Les Fausses Confidences Stratagme, Les Fromagers De Thirache Horaires, Archange Gabriel Pouvoir, Adeline Franois Mari, Rdiger Un Rapport Sur Un lve En Difficult .
MIRCERA Dosage & Rx Info | Uses, Side Effects - MPR OZZ Macdougall IC, Obrador GT, El Nahas M. How important is transfusion avoidance in 2013? Although the reasons for transfusion were not recorded, the pre-transfusion Hb concentrations within 14days prior to transfusion remained similar for transfusions occurring both pre- and post-switch. Anemia: an early complication of chronic renal insufficiency. In pediatric patients, Mircera is administered by intravenous injection only (2.2). Summary of the last hemoglobin concentrations recorded within 14days prior to red blood cell transfusions pre- and post-switch. The initial conversion factor was 200:1. Regression analysis indicated a non-linear relationship between pre- and post-switch ESA doses; DCR decreased with increasing pre-switch DA dose.
Methods: Optimizing the use of erythropoietic agentspharmacokinetic and pharmacodynamic considerations. Do not use any prefilled syringes exhibiting particulate matter or a coloration other than colorless to slightly yellowish. There were 16 transfusion events in the pre-switch period and 48 post-switch, with a total of 34 units transfused pre-switch and 95 units in the post-switch period (Fig. Blistering and skin exfoliation reactions including Erythema multiforme and Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN), have been reported in patients treated with ESAs (including Aranesp, Serious and fatal reactions including gasping syndrome can occur in neonates and infants treated with benzyl alcohol-preserved drugs, including EPOGEN. Patients stable on intravenous (iv) epoetin alfa will be randomized either to receive standard of care therapy (epoetin alfa (iv) 3 times weekly), or to receive Mircera 120-360 micrograms (iv), monthly. In an additional analysis performed to assess the sensitivity of this result to the effects of transfusion by excluding those patients who received an RBC transfusion within 90days prior to or during either evaluation period, the DCR was 1.21 (95% CI 1.09, 1.35). You may also report negative side effects of prescription drugs to the Food and Drug Administration (FDA). . Of 302 patients enrolled, 206 had data available for DCR analysis. 4. Conversion from Another ESA: dosed once every 4 weeks based on total weekly epoetin alfa or darbepoetin alfa dose at time of conversion (2.2). Patients included in the analysis were less likely to be diabetic (32% vs. 40%), more likely to be receiving DA at a longer dosing interval (60% vs. 73% at QW; 19% vs. 3% less frequently than Q2W), and received a lower geometric mean weekly dose of DA during the pre-switch EP (24.1 vs. 37.7g). -, Macdougall IC. ONLY administer MIRCERA intravenously in pediatric patients. The study sample comprised adult patients (age 18years) with CKD who received maintenance hemodialysis between January 2008 and August 2011 and whose ESA treatment was switched from IV DA to IV PEG-Epo. Bethesda, MD 20894, Web Policies The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Indication Aranesp (darbepoetin alfa) is indicated for the treatment of anemia due to chronic kidney disease (CKD), including patients on dialysis and patients not on dialysis.Limitations of Use Aranesp has not been shown to improve quality of life, fatigue, or patient well-being. Anemia: an early complication of chronic renal insufficiency. This article does not contain any studies with human or animal subjects performed by any of the authors.
American Society of Hematology Self-Assessment Program (Adam - Scribd ^D[5j@%e Report to the Judicial Council. Aranesp (darbepoetin alfa) prescribing information, Amgen. For the purposes of this policy, a conversion factor of 3 should be used to estimate hematocrit when only the hemoglobin is measured, e.g., hemoglobin of 10 g/dL is approximately equal to a hematocrit of 30%, a hemoglobin of 11 g/dL is . Excluding patients receiving a transfusion within 90 days of or during either EP, the DCR was 1.21 (95% CI 1.09, 1.35). Kazmi WH, Kausz AT, Khan S, et al. Therapeutic effects . Epoetin alfa was the first rhEPO produced and approved for pharmaceutical use, followed by several related products and by newer ESAs with the same mechanism but more prolonged action. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. methoxypolyethylene glycol-epoetin beta (meh-thok-see-pah-lee-eh-thih-leen gly-kol ee-poh-eh-tin bay-ta) , Mircera (trade name) Classification Therapeutic: antianemics Pharmacologic: hormones Pregnancy Category: C Indications Anemia due to chronic renal failure.
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