Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Identification of small molecule activators of cryptochrome. What is the potential role of antifibrotic agents for the treatment of liver disease? Genomics of liver fibrosis and cirrhosis. Cell Metab. Note that an individual publication can be assigned to more than one field. 2015 Jul; 22(7):512-8. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. FASEB J. Yale J Biol Med. 1998 Feb 15; 101(4):802-11. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. 2004 Dec; 127(6):1659. 2019 03; 156(4):1156-1172.e6. Biochem Soc Symp. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Am J Physiol Cell Physiol. J Neurol. Hepatology. 2001 Jan; 280(1):G139-48. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. Allergy. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. 1999 Aug; 31(4):305-19. 2009 May; 40(5):1721-8. Mol Ther Nucleic Acids. Hepatology. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. Hepatology. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. 2004 Nov; 40(5):1106-15. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. 2006 Sep; 131(3):957-60. Gastroenterology. 2004 Aug 15; 78(3):324-32. J Burn Care Rehabil. Int Psychogeriatr. 2015 Mar; 29(3):1043-55. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. J Hepatol. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Am J Physiol. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Clin Res Hepatol Gastroenterol. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Nature. 1999 03; 276(3):G591-8. 2010 Sep; 139(3):836-45, 845.e1. 2016 Aug; 38(4):291-302. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Mol Cell Biol. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. 2001 Jul 01; 167(1):173-80. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2002 Sep; 123(3):877-8. Gastroenterology. 2015 May; 31(3):184-91. 2000 Feb; 88(2):142-9. 2022 09; 609(7925):101-108. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Researchers can. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. 2018 12; 68(6):2059-2061. Hepatology. Aging Ment Health. 1994 Dec 09; 269(49):30789-97. 2014 Jul; 124(7):2921-34. N Engl J Med. Studies with human cultured skin fibroblasts. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. Analysis of the human ferrochelatase promoter in transgenic mice. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. 1997 10; 273(4):G795-803. 2006 Jul; 131(1):272-5. 2020 05; 158(6):1728-1744.e14. Gastroenterology. 2016 Mar; 13(3):126-8. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. Activation of activating protein 1 during hepatic acute phase response. 1996 Sep; 50(3):656-61. 2012 Mar; 27 Suppl 2:65-8. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 1990; 14(6):639-45. 1994 Jul 29; 269(30):19203-6. 2020 May 05; 56(5). Vuori will Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. Toll-like receptors and adaptor molecules in liver disease: update. Promising Therapy Candidates for Liver Fibrosis. 2012 Nov; 143(5):1330-1340.e1. Proc Natl Acad Sci U S A. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Dig Dis Sci. Cell Mol Gastroenterol Hepatol. 2015 Sep; 39 Suppl 1:S75-9. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. J Hepatol. 2013; 8(2):e56116. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. J Clin Invest. 1998 10; 275(4):C1058-66. WebDavid Brenner. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. J Clin Gastroenterol. Gene Expr. 1990; 24:352-8. 1992 Feb 28; 183(1):184-92. Gastroenterology. This graph shows the total number of publications by year. 2011 Apr; 300(4):G516-25. Clinical syndromes of alcoholic liver disease. 2013 Mar; 62(3):335-6. Gut. NF-kappaB activation in Kupffer cells after partial hepatectomy. Gastroenterology. 2006 May; 130(6):1562. 2008 Nov; 48(5):1420-9. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Gastroenterology. Alcohol Clin Exp Res. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Hepatology. 2012 Nov; 13(11):1072-82. 2021 12 09; 12(1):7172. Front Physiol. 1998 May; 114(5):1035-45. 1989 Aug 15; 49(16):4446-51. Alcohol Clin Exp Res. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. 2018 06; 67(6):2150-2166. Cell Metab. J Biol Chem. 2001 Jul; 34(1):89-100. Am J Physiol Gastrointest Liver Physiol. Mol Cell Biol. Inactivation of myofibroblasts during regression of liver fibrosis. Blood. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 1991 12; 54(6 Suppl):1141S-1143S. 2004 Jun; 135(6):619-28. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. Liver Int. Nature. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. 2019 11 05; 30(5):850-852. 1998 Aug 10; 1366(1-2):177-96. Alcohol Clin Exp Res. Semin Liver Dis. 2007 Nov; 2(4):243-4. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Hepatology. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. 2016 Feb; 43(2):179-87. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. 2015 Feb; 4(1):34-47. 2005 Nov; 29(11 Suppl):102S-109S. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Nuclear factor-kappaB in the liver: friend or foe? Proc Natl Acad Sci U S A. Nat Clin Pract Gastroenterol Hepatol. Proc Natl Acad Sci U S A. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Hepatology. 2007 Nov; 13(11):1324-32. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Neurobiol Aging. 1998 Oct; 27(3):192-8. Exp Neurol. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Hepatology. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Cloning of murine ferrochelatase. 2017 10 10; 114(41):10808-10809. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Gastroenterology. Hepatol Commun. Role of Gut Microbiota in Liver Disease. 2012; 7(4):e34218. Hepatic porphyrias. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Cell Death Differ. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. 1999 Jan; 30(1):77-87. Next-generation academic medicine. Expression of collagen genes in the liver. 2016; 7:17. 1993 Apr; 264(4 Pt 1):G589-95. Cell Death Differ. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Anti-fibrogenic strategies and the regression of fibrosis. Heterogeneity of HSCs in a Mouse Model of NASH. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. J Clin Gastroenterol. Clin Gastroenterol Hepatol. 1988 Jan-Feb; 8(1):176-82. Hepatology. 1994 Oct; 267(4 Pt 1):G552-61. Role of NADPH oxidases in liver fibrosis. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. Expression of human immunodeficiency virus-1 in human colonic cells. Hepatology. J Clin Invest. 2009; 44 Suppl 19:1-7. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. J Immunol. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Arch Biochem Biophys. 2005 Dec; 42(6):1320-8. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2008 Aug; 42(5):349-61. Fra, Fra away: the complex role of activator protein 1 in liver injury. Am J Physiol Gastrointest Liver Physiol. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. To see the data as text. 2005 Sep; 230(8):573-86. Hepatology. 1994 Sep; 14(9):5950-60. 2007 Apr-Jun; 6(2):83-8. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. 1989 May; 9(5):2224-7. 2009 Jul; 50(1):185-97. 2007 Jun 15; 462(2):266-72. People in Profiles who have published with this person. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. Stroke. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Mol Endocrinol. Molecular and cellular biology of the small intestine. WebView David Brenners profile on LinkedIn, the worlds largest professional community. 1999 Mar; 15(2):103-7. 2005; 23(3-4):264-74. Ceramide activates the stress-activated protein kinases. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Proc Natl Acad Sci U S A. Hepatology. Hepatology. Liver Transpl. CCR1 and CCR5 promote hepatic fibrosis in mice. Mechanisms of hepatic toxicity. Gastroenterol Res Pract. Gastroenterology. Dig Dis. Am J Physiol Gastrointest Liver Physiol. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. Mol Cell Biol. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. 1995 Feb; 95(2):803-10. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Nucleic Acids Res. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. 41 ):10808-10809 phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor factor-alpha. Forman DT mediates fibrotic and inflammatory effects of leptin on hepatic stellate cell activation in vivo cells secrete angiopoietin that! ( 11 Suppl ):102S-109S inactive phenotype during regression of liver disease:.... 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